3-溴甲苯酸
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- CAS号:
- 1113-59-3
- 英文名:
- 3-Bromopyruvic acid
- 英文又名:
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
- 中文名:
- 3-溴丙酮酸
- 中文又名:
- 溴丙酮酸;3-溴庚酸;3-溴丙酮酸;3-溴代丙酮酸;溴丙酮酸,97%;3-溴丙酮酸97%;3-溴-2-氧代丙酸;3-溴-2-氧代丙酸3-溴丙酮酸;PERFEMIKER]溴丙酮酸,95%;3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- CBNumber:
- CB0380692
- 份子式:
- C3H3BrO3
- 份子量:
- 166.96
- MOL File:
- 1113-59-3.mol
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3-溴二甲苯酸化学性子
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融点:
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77-82 °C
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凝固点:
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223.4±23.0 °C(Predicted)
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体积密度:
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1.7314 (rough estimate)
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折射角率:
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1.4650 (estimate)
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存储要素:
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2-8°C
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消融度:
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water: soluble1g/10 mL, clear, colorless
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图形:
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White crystalline solid
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酸度标准值(pKa):
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1.84±0.54(Predicted)
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暖色调:
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White to Almost white
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水消融性:
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Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
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BRN:
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1746786
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InChIKey:
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PRRZDZJYSJLDBS-UHFFFAOYSA-N
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CAS 数值库:
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1113-59-3(CAS DataBase Reference)
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EPA电化学工程设备数据信息:
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3-溴异丙醇酸性子、用处与出产工艺
3-Bromopyruvic acid 是己糖激酶 II (hexokinase II, HXK II) 按捺剂,是一种有用的针对肝癌细胞的抗肿瘤剂。
3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells.
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress.
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels.
Cell Viability Assay
Cell Line:
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MCF-7 and MDA-MB-231 cells
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Concentration:
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40, 80, 160 or 320 µM
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Incubation Time:
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24 hours
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Result:
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3-Bromopyruvate (80 and 160 µmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
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3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice.
Animal Model:
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Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)
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Dosage:
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8 mg/kg
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Administration:
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I.p.; every 4 days for 28 days
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Result:
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Showed antitumor efficacy in tumor xenografts.
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化学性子
3-溴代丙酮酸是红色固体,m.p.64~67℃。不溶于水。
用处
3-溴代丙酮酸是杀菌剂噻菌灵的中心体。
用处
半胱氨酸残基的亲和标记;核酸和卵白质之间的交联剂
出产方式
其制备方式是将丙酮酸中加入少量浓硫酸和溶剂二氯甲烷置于反映瓶中,滴加溴约需3.5h,并搅拌,有红色积淀发生,再持续搅拌1h,用环己烷和煤油醚浓缩,而后冷却反映夹杂物获得结晶,过滤,用煤油醚洗濯并枯燥获得产物。
种别
有毒物资
毒性分级
高毒
急性毒性
腹腔-小鼠 LD50: 72 毫克/千克
可燃性风险特征
热分化排挤有毒溴化物蒸汽
储运特征
库房透风高温枯燥; 与食物质料分隔寄存
灭火剂
泡沫、干粉、二氧化碳、雾状水
3-溴二甲苯酸
高低游产物信息
下流质料
下流产物
更新日期 | 产物编号 | 产物称号 | CAS编号 | 包装 | 价钱 |
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2024/04/30 | L00720 | 溴丙酮酸, 97% Bromopyruvic acid, 97% | 1113-59-3 | 2g | 348元 |
2024/04/30 | L00720 | 溴丙酮酸, 97% Bromopyruvic acid, 97% | 1113-59-3 | 50g | 3683元 |
3-溴甲苯酸
出产厂家
环球有 320家供给商
3-溴丙酮酸国际出产厂家
1113-59-3, 3-溴甲苯酸 相干搜刮:
- Piperidines
- Carboxylic Acids
- Organic acids
- Carboxylic Acids
- Aliphatics
- 高端化学
- 无机化学
- 无机化工
- 资料中心体及助剂
- 细胞生物学试剂
- 农药质料
- 苯并咪唑类杀菌剂
- 羰基化合物
- 无机酸
- 无机砌块
- 羧酸
- 通用试剂
- 杀菌剂中心体
- 农药中心体
- Organic Building Blocks
- C1 to C5
- Carbonyl Compounds
- Carboxylic Acids
- Building Blocks
- C3H3BrO3
- BrCH2COCOOH
- C3H3O3Br
- 优选]3-BROMOPYRUVIC ACID
- PERFEMIKER]溴丙酮酸,95%
- HEXOKINASE II(己糖激酶II)按捺剂(3-BROMOPYRUVIC ACID)
- 3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- 3-溴代丙酮酸
- 溴丙酮酸
- 3-溴丙酮酸97%
- 3-溴-2-氧代丙酸
- 3-溴庚酸
- 3-溴-2-氧代丙酸3-溴丙酮酸
- 3-溴丙酮酸
- 溴丙酮酸,97%
- 1113-59-3
- 3-Bromopyruvic Acid, ≥ 98.0%
- Bromopyruvic acid (3-bromopyruvic acid)
- beta-bromopyruvicacid
- 3-BROMO-2-OXOPROPIONIC ACID
- BROMOPYRUVIC ACID
- 3-BROMOPYRUVIC ACID
- 3-bromopyruvate
- bromopyruvate
- 2-Oxo-3-bromopropanoic acid
- 3-BROMO-2-OXOPROPANOIC ACID
- Bromopyruvic acid,98%
- 3-Bromopyruvic Acid >
- 3-Brom-2-oxopropionsure
- Hexokinase II Inhibitor II
- 3-Bromopyruvic acid (3-BP)
- 4-Amino-5-(aminocarbonyl)imidazole H
- BROMOPYRUVIC ACID;3-BROMOPYRUVATE
- Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem